资源类型

期刊论文 372

会议视频 3

年份

2023 42

2022 38

2021 28

2020 29

2019 17

2018 31

2017 21

2016 13

2015 26

2014 16

2013 9

2012 6

2011 12

2010 13

2009 9

2008 15

2007 18

2006 5

2005 2

2004 4

展开 ︾

关键词

农业面源污染 2

大气污染 2

1)幂模型 1

2-基展开 1

2R-1C模型；嵌入式系统；参数估计；非迭代方法；二次型 1

3D细胞容器 1

Beclin-1 1

Bent函数 1

China TIMES模型 1

GIS 1

GM(1 1

MOF基催化剂 1

PP 1

SARS-CoV-2 1

SARS-CoV-2干扰 1

SIMPLEC算法 1

SPSS 1

WPC 1

circRNA 1

展开 ︾

检索范围：

排序： 展示方式：

Insights into the electron transfer mechanisms of permanganate activation by carbon nanotube membrane for enhanced micropollutants degradation

《环境科学与工程前沿（英文）》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1706-0

摘要：

● A CNT filter enabled effective KMnO4 activation via facilitated electron transfer.

关键词： KMnO4     Carbon nanotubes     Non-radical pathway     Electron transfer     Water treatment    

HTML PDF 收藏

structured -FeO/MoS effectively activated peroxymonosulfate for efficient abatement of bisphenol A via both radicaland non-radical pathways

《环境科学与工程前沿（英文）》 2023年 第18卷 第3期 doi: 10.1007/s11783-024-1797-2

摘要：

● Magnetic Co- γ -Fe2O3/MoS2 were prepared via facile hydrothermal methods.

关键词： Magnetic Co-γ-Fe2O3/MoS2     Hydrothermal method     Bisphenol A     Degradation pathways     Toxicity analysis    

HTML PDF 收藏

Bacteria inactivation by sulfate radical: progress and non-negligible disinfection by-products

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1629-9

摘要：

● Status of inactivation of pathogenic microorganisms by SO4•− is reviewed.

关键词： Sulfate radicals     Disinfection by-products     Inactivation mechanisms     Bacterial inactivation     Water disinfection    

HTML PDF 收藏

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stagecervical cancer: a randomized, non-inferiority, multicenter trial

《医学前沿（英文）》 2023年 第17卷 第1期   页码 93-104 doi: 10.1007/s11684-021-0892-z

摘要： We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757; P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment.

关键词： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

HTML PDF 收藏

MOF-5@Ni衍生的ZnO@Ni3ZnC0.7/PMS体系用于有机物去除——对吸附-降解过程的深入理解 Article

帅又文, 黄雪, 张本银, 项璐, 徐浩, 叶倩, 鲁金凤, 张静

《工程（英文）》 2023年 第24卷 第5期   页码 254-264 doi: 10.1016/j.eng.2021.08.029

摘要：

基于过一硫酸盐的非均相催化活化技术在废水处理中越来越受到关注。因此，找到一种可持续、经济、有效的活性材料用于废水处理非常重要。本研究以金属有机框架材料（MOF）-5 为前驱体，通过添加镍离子并随后煅烧制备了一种稳定、可循环利用的材料ZnO@Ni3ZnC0.7，该材料表现出良好的吸附和催化性能。为了研究和优化实际应用条件，选择了罗丹明B（RhB）在水中的降解作为模型过程。研究表明，体系中有机物的去除涉及吸附和降解过程的耦合。基于此，提出了整个去除过程的机理。扫描电子显微镜、红外光谱分析和理论分析的结果证实，范德华力、静电吸引力和氢键影响吸附过程。电子顺磁共振分析、遮蔽实验和电化学测试证实，RhB的降解路径包括自由基和非自由基途径，表面羟基是关键的活性位点。对吸附底物的降解使活性位点得到再生。用简单方法再生的材料在4 个循环测试中对有机化合物保持很高的去除效率。此外，这种材料还可以有效地去除各种有机污染物，并且由于具有磁性，材料易于回收。结果表明，使用具有良好吸附能力的非均相催化材料可能是一种经济有效的策略。

关键词： MOF基催化剂     过一硫酸盐     吸附     自由基     非自由基    

HTML PDF 收藏

Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

《医学前沿（英文）》 2010年 第4卷 第1期   页码 112-116 doi: 10.1007/s11684-010-0016-7

摘要： We conducted a trial to assess the influence of closure or nonclosure of the peritoneum and subcutaneous tissue on the clinical outcomes of cervical cancer patients who underwent radical hysterectomy with lower abdominal cross incision. This randomized controlled trial was performed on 158 cervical cancer patients in our hospital between January 2002 and June 2004. Eighty-two patients were allocated to the “closure” group and 76 patients to the “nonclosure” group. Results showed that non-closure of the peritoneum and subcutaneous tissue could shorten operation time and febrile duration, reduce antibiotics requirement, increase the volume of drainage and decrease the incidence of liquefaction of subcutaneous fat (<0.05). There was no difference in blood loss, postoperative complications, bowel function restoration and post-operative stay between the two groups (>0.05). Our study revealed that closure of the peritoneum and subcutaneous tissue provides no immediate postoperative benefits while unnecessarily lengthening surgical time and anesthesia exposure. The practice of closure of the peritoneum and subcutaneous tissue at radical hysterectomy should be questioned.

关键词： cervical cancer     radical surgery     peritoneum     subcutaneous tissue    

HTML PDF 收藏

Hydroxyl radical-involved cancer therapy via Fenton reactions

《化学科学与工程前沿（英文）》 2022年 第16卷 第3期   页码 345-363 doi: 10.1007/s11705-021-2077-3

摘要： The tumor microenvironment features over-expressed hydrogen peroxide (H2O2). Thus, versatile therapeutic strategies based on H2O2 as a reaction substrate to generate hydroxyl radical (•OH) have been used as a prospective therapeutic method to boost anticancer efficiency. However, the limited Fenton catalysts and insufficient endogenous H2O2 content in tumor sites greatly hinder •OH production, failing to achieve the desired therapeutic effect. Therefore, supplying Fenton catalysts and elevating H2O2 levels into cancer cells are effective strategies to improve •OH generation. These therapeutic strategies are systematically discussed in this review. Furthermore, the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed to improve therapeutic efficacy.

关键词： hydroxyl radical     Fenton catalyst     hydrogen peroxide     cancer therapy    

HTML PDF 收藏

Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 74-86 doi: 10.1007/s11684-017-0503-1

摘要：

β-thalassemia is caused by β-globin gene mutations. However, heterogeneous phenotypes were found in individuals with same genotype, and still undescribed mechanism underlies such variation. We collected blood samples from 30 β-thalassemia major, 30 β-thalassemia minor patients, and 30 matched normal controls. Human lncRNA Array v2.0 (8 × 60 K, Arraystar) was used to detect changes in long non-coding RNAs (lncRNAs) and mRNAs in three samples each from β-thalassemia major, β-thalassemia minor, and control groups. Compared with normal controls, 1424 and 2045 lncRNAs were up- and downregulated, respectively, in β-thalassemia major patients, whereas 623 and 349 lncRNAs were up- and downregulated, respectively, in β-thalassemia minor patients. Compared with β-thalassemia minor group, 1367 and 2356 lncRNAs were up- and downregulated, respectively, in β-thalassemia major group. We selected five lncRNAs that displayed altered expressions (DQ583499, X-inactive specific transcript (Xist), lincRNA-TPM1, MRFS16P, and lincRNA-RUNX2-2) and confirmed their expression levels in all samples using real-time polymerase chain reaction. Based on coding-non-coding gene co-expression network and gene ontology biological process analyses, several signaling pathways were associated with three common organ systems exhibiting β-thalassemia phenotypes: hematologic, skeletal, and hepatic systems. This study implicates that abnormal expression levels of lncRNAs and mRNA in β-thalassemia cases may be correlated with its various clinical phenotypes.

关键词： β-thalassemia     long non-coding RNA     mRNA     phenotypic heterogeneity     pathway    

HTML PDF 收藏

Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1637-9

摘要：

● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.

关键词： Xylose fermentation     Caproate     Low temperature     Bifidobacterium     FAB pathway     RBO pathway    

HTML PDF 收藏

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

《医学前沿（英文）》 2023年 第17卷 第4期   页码 714-728 doi: 10.1007/s11684-022-0959-5

摘要： FRMD6, a member of the 4.1 ezrin–radixin–moesin domain-containing protein family, has been reported to inhibit tumor progression in multiple cancers. Here, we demonstrate the involvement of FRMD6 in lung cancer progression. We find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung tissues. In addition, the enhanced expression of FRMD6 is associated with poor outcomes in patients with lung squamous cell carcinoma (n = 75, P = 0.0054) and lung adenocarcinoma (n = 94, P = 0.0330). Cell migration and proliferation in vitro and tumor formation in vivo are promoted by FRMD6 but are suppressed by the depletion of FRMD6. Mechanistically, FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of the mTOR signaling pathway. FRMD6 markedly enhances the interaction between mTOR and S6K, subsequently increasing the levels of endogenous pS6K and downstream pS6 in lung cancer cells. Furthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6−/− gene KO MEFs and mice. Altogether, our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway.

关键词： FRMD6     lung cancer     mTOR pathway    

HTML PDF 收藏

Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 157-162 doi: 10.1007/s11684-011-0128-8

摘要： At present, clinical pathway has become one of the most important health care reform measures in many countries. In this study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-based Chinese medicine incorporated with the methodology from the concepts of management, evidence-based medicine, operational research and health economics. Such concepts provide examples and experiences, on which the application of clinical pathway in Chinese medicine practice in China can be based.

关键词： evidence-based medicine     clinical pathway     methodology     concept     technical difficulty    

HTML PDF 收藏

Free radical scavenging window of infertile patients with polycystic ovary syndrome: correlation with

null

《医学前沿（英文）》 2017年 第11卷 第2期   页码 247-252 doi: 10.1007/s11684-017-0519-6

摘要：

The activity of free radicals in follicular fluid was related to ovarian responsiveness, in vitro fertilization (IVF), and embryo transfer success rate. However, studies analyzing the relationship between the free radical scavenging capacity and embryo quality of infertile women with polycystic ovarian syndrome (PCOS) were lacking. The aim of this study was to evaluate the relationship between the free radical scavenging window of women with PCOS and their embryo quality. The free radical scavenging capacity of follicular fluid from women with PCOS was determined by a,a-diphenyl-b-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethylbenzthiazoline-6-sulphonic acid) assay, superoxide radical, and reactive oxygen species (ROS) assay. In the DPPH and ROS assays, the follicular fluid from grades I and II embryos was significantly higher than the follicular fluid from grades III and IV embryos. The lower control limit of DPPH radical scavenging capacity and upper control limit of ROS level were 13.2% and 109.0 cps, respectively. The calculated lower control limit and upper control limit were further confirmed in the follicular fluid of embryos of all grades. These cut-off values of free radical scavenging activity of follicular fluid could assist embryologists in choosing the development of embryos in PCOS patients undergoing IVF.

关键词： in vitro fertilization     PCOS     free radical     embryo quality    

HTML PDF 收藏

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 403-409 doi: 10.1007/s11684-017-0522-y

摘要：

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.

关键词： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle cells    

HTML PDF 收藏

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

《医学前沿（英文）》 2022年 第16卷 第4期   页码 637-650 doi: 10.1007/s11684-021-0864-3

摘要： Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment. We tested the potential effect of apigenin, a natural flavonoid with anticancer, anti-inflammatory, and antioxidant activities, on neomycin-induced ototoxicity in cochlear hair cells in vitro. Results showed that apigenin significantly ameliorated the loss of hair cells and the accumulation of reactive oxygen species upon neomycin injury. Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway was activated by apigenin treatment. Disruption of the Nrf2 axis abolished the effects of apigenin on the alleviation of oxidative stress and subsequent apoptosis of hair cells. This study provided evidence of the protective effect of apigenin on cochlear hair cells and its underlying mechanism.

关键词： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

HTML PDF 收藏

Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 285-293 doi: 10.1007/s11684-014-0350-2

摘要：

Catharanthus roseus is one of the most extensively investigated medicinal plants, which can produce more than 130 alkaloids, including the powerful antitumor drugs vinblastine and vincristine. Here we review the recent advances in the biosynthetic pathway of terpenoid indole alkaloids (TIAs) in C. roseus, and the identification and characterization of the corresponding enzymes involved in this pathway. Strictosidine is the central intermediate in the biosynthesis of different TIAs, which is formed by the condensation of secologanin and tryptamine. Secologanin is derived from terpenoid (isoprenoid) biosynthetic pathway, while tryptamine is derived from indole biosynthetic pathway. Then various specific end products are produced by different routes during downstream process. Although many genes and corresponding enzymes have been characterized in this pathway, our knowledge on the whole TIA biosynthetic pathway still remains largely unknown up to date. Full elucidation of TIA biosynthetic pathway is an important prerequisite to understand the regulation of the TIA biosynthesis in the medicinal plant and to produce valuable TIAs by synthetic biological technology.

关键词： Catharanthus roseus     terpenoidindole alkaloids     biosynthetic pathway     vinblastine     vincristine    

HTML PDF 收藏

标题 作者 时间 类型 操作

Insights into the electron transfer mechanisms of permanganate activation by carbon nanotube membrane for enhanced micropollutants degradation

期刊论文

structured -FeO/MoS effectively activated peroxymonosulfate for efficient abatement of bisphenol A via both radicaland non-radical pathways

期刊论文

Bacteria inactivation by sulfate radical: progress and non-negligible disinfection by-products

期刊论文

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stagecervical cancer: a randomized, non-inferiority, multicenter trial

期刊论文

MOF-5@Ni衍生的ZnO@Ni3ZnC0.7/PMS体系用于有机物去除——对吸附-降解过程的深入理解

帅又文, 黄雪, 张本银, 项璐, 徐浩, 叶倩, 鲁金凤, 张静

期刊论文

Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

期刊论文

Hydroxyl radical-involved cancer therapy via Fenton reactions

期刊论文

Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major

null

期刊论文

Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

期刊论文

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

期刊论文

Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

期刊论文

Free radical scavenging window of infertile patients with polycystic ovary syndrome: correlation with

null

期刊论文

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

期刊论文

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

期刊论文

Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

null

期刊论文